Semaglutide and Tirzepatide are the hot new weight loss medications on the market. If you’re considered overweight and struggle with losing weight through traditional methods, then you may want to consider one of these two treatments.

Both are FDA-approved and are known to stimulate weight reduction in those who have trouble maintaining a healthy body weight.

So, what’s the difference between Semaglutide and Tirzepatide, and which one is best when it comes to weight management?

Continue reading to learn more about these two types of weight-loss injections and which might be best for you.

Semaglutide vs Tirzepatide

What is Semaglutide?

Semaglutide is a glucagon-like peptide 1 receptor receptor substance that reduces appetite so the user minimizes their food intake. Branded medications like Ozempic have risen in popularity over the years when it comes to treating type 2 diabetes and weight management. 

What is Tirzepatide?

Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor substance that regulates blood sugar levels and stimulates weight loss, making it a life-changing treatment for those diagnosed with type 2 diabetes. Tirzepatide works by controlling blood sugar and slowing down digestion; this causes the user to feel full faster. 

A popular Tirzepatide on the market is Mounjaro.

Which Drug is More Effective?

After many studies, results showed that Tirzepatide stimulates more weight reduction than Semaglutide. However, Semaglutide has been around much longer than Tirzepatide, which means we have a better understanding of its long-term effects.

How Do I Qualify For Either Medication?

If you’re obese, overweight, or have type 2 diabetes, then you may qualify for either medication. If you’re at risk for cardiovascular disease, then you may be a better candidate for Tirzepatide.

Your doctor will assess your medical history to determine if you’re a proper candidate and which medication will be best for you.

Are There Side Effects of Either Medication?

Yes — there are side effects to taking either Semaglutide or Tirzepatide. Read the side effects below. 


  • Thyroid tumors/cancer
  • Pancreatic inflammation
  • Low blood sugar
  • Allergic reactions
  • Problems with kidney, vision, or gallbladder


  • Thyroid tumors/cancer
  • Kidney problems
  • Allergic reactions
  • Problems with vision or pancreas 
  • Low blood sugar

If you have a history of any issues regarding the potential side effects, discuss those with your doctor so they can determine if you’re still an ideal candidate for one of these medications.

Here at Mason Park Medical Clinic, our providers are trained in assessing your overall health and determining the best weight loss medication to help you achieve your health goals. If you have questions about Tirzepatide or Semaglutide, we encourage you to give us a call so you can learn more about both medications and see if either is an appropriate treatment for you.

Our goal is to help you live your best and healthiest life. Schedule an appointment with us today so you can begin your weight loss journey.